Prominent features of planarian biologyabundant stem cells, robust regeneration, restoration of missing tissue patterns and cell types, and homeostatic replacement of aged cellscan thus. Howard hughes medical institute 2006 holiday lectures on science this activity was created in support of the 2006 holiday lectures on science on stem cells. It usually describes freeliving flatworms of the order tricladida triclads, although this common name is also used for a wide number of freeliving platyhelminthes. Planaria lab tracy blanchard, meghan emmett, ethan grammer, owen denn 4. Postmerger integration how to achieve quick wins and. This plan of merger is a product of the transition board, in consultation with their respective boards and legal counsel. Jul 24, 20 although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known. These plans are primarily focused on land development and housing and do not consider wider regeneration issues. Only one type of cell in a planaria the neoblastis capable of dividing. Jul 24, 20 species capable of regenerating lost body parts occur throughout the animal kingdom, yet close relatives are often regeneration incompetent 1,2. How to merge pdf files into one single document online. Agreement and plan of merger by and between the bear stearns. In an effort to mechanistically address these issues, we. The 1focus seven step model figure 4 moves the organization from the top of the clevel executive team and the project integration team down and outwards through the organization.
Whether regeneration is part of the development of an animal or a distinct phenomenon independent of. Planarian regeneration in response to drug disruption of the wnt and mapk pathways the regenerative ability of planarians depends largely on its complex signaling pathways. Planarian worm regeneration and regrowing lost limbs 27th september 2015 by alexander 2 comments in this article we look at research with planarian worm regeneration and how it could lead to soon regrowing lost limbs in humans. In other words, all assets and liabilities of the transferor company become that of the transfer company. Therefore, currently there is no overarching regeneration plan for each neighbourhood that. The closing of the merger shall take place at the offices of. Species capable of regenerating lost body parts occur throughout the animal kingdom, yet close relatives are often regeneration incompetent 1,2. In this laboratory, you will use planaria to study animal regeneration, as well as animal growth and development.
Building a mergerready organization is an ongoing and continuous effort, and following these five steps will result in a strong platform to realize the benefits of merger and acquisition. Planarian regeneration freshwater planarians have amazed scientists since the first descriptions of their great regenerative capabilities reported already at the end of the 18th century. The term effective time shall be the date and time when the merger becomes effective as set forth in the certificate of merger. Gustafson and michael hergert this article describes some acquisition pitfalls and how to avoid them. Jan 11, 2018 amalgamation is defined as the combination of one or more companies into a new entity. This plan of merger is made and entered into as of the 30 day of january, 2008 between hybred international, inc. Pastor andy and the merger team will lead an open forum concerning the proposed merger to answer any and all questions about the merger. Nov 09, 2012 third, the ability of planarians to maintain their body plan in face of constant turnover is simply fascinating. Name a name will be selected for the merged entity as set out below. Regeneration definition and meaning collins english. The work, published online in elife, is the first to discover that adult stem cells called neoblasts, key to planaria regeneration, arise during a specific stage of embryonic development.
Fundamentals of planarian r university of illinois. From and after the effective time, all certificates. Free web app to quickly and easily combine multiple files into one pdf online. Planaria are common to many parts of the world, living in both saltwater and freshwater ponds and rivers. Digestive enzymes are secreted from the mouth to begin external digestion. Billman 1 kianna billman bio 451 american university. Using planarian flatworms to understand organ regeneration. Regeneration technologies, tutogen medical announce new name. If a structure is lost during the intermoult phase it can only regenerate in proportion to how much of the intermoult phase is left for pattern reestablishment and differentiative mitoses. Do all planaria regenerate as quickly as the planariidae. Post merger integration plan acquisition integration. We are at odds in explaining regeneration as an evolutionary variable brockes et al. Our pdf merger allows you to quickly combine multiple pdf files into one single pdf document, in just a few clicks. School of molecular and cellular biology, university of illinois, urbana.
A window on regeneration we humans prefer to avoid getting our limbs cut o once your arm is gone, thats it. This article is published with open access at abstract planarians are members of the platyhelminthes flatworms. Piwilike proteins are known to be functionally associated with stem cell activities, yet little is known about how piwi proteins regulate stem cells. Possible key to regeneration found in planarias origins. Planarian regeneration magic and immortality bidirectional regeneration is really amazing, but not even this can compete with the planaria, living a mundane existence in a pond but with amazing scientific secrets to be discovered. Whether regeneration is part of the development of an animal or a distinct phenomenon independent of development is a debatable question. In most cases, regeneration should be complete within a week to ten days. Seven steps to merger excellence ivey business journal. In order to do this we have three specific objectives. Planarian regeneration in response to drug disruption of.
The wnt pathway regulates the ap polarity formation after regeneration, while the mapk pathway plays a role in regeneration. Approval by members this plan of merger shall be submitted for the approval of the members of each corporation in the manner provided by the applicable laws of the state of wisconsin and the state of minnesota at meetings to be held on or before july 9, 2009, or at such other time as to which the board of directors of each corporation. To identify genes required for pharynx regeneration, we performed an rnai screen of 356 genes upregulated after amputation, using successful feeding as a proxy for regeneration. The digestive system consists of a mouth, pharynx, and a gastrovascular cavity. The principles underlying regeneration in planarians have been explored for over 100 years through surgical manipulations and cellular observations. The purpose of this lab was to assess the regenerative abilities of planarians under. You will learn how to collect and culture planaria from different environments to study how environmental conditions can affect regeneration and growth and development. Agreement and plan of merger this agreement and plan of merger, dated as of february 14, 2005 this agreement, is among verizon communications inc. To start, drop your first pdf file or upload it from your device or your cloud storage service. Regeneration governance and project management arrangements. Apr 26, 2011 merger is a fusion between two or more enterprises, whereby the identity of one or more is lost and the result is a single enterprise whereas amalgamation signifies blending of two or more existing undertakings into one undertaking, the blended companies losing their identities and forming themselves into a separate legal identity. This free online tool allows to combine multiple pdf or image files into a single pdf document. Planaria, petri dishes, and other equipment are available from biological supply companies at modest cost. With pdf merger you can merge your multiple pdf files to a single pdf file in matter of seconds.
As specified in the certificate of merger, the merger shall be effective as of 12. Here we describe a singleorgan regeneration assay in which ejection of the planarian pharynx is selectively induced by brief exposure of animals to sodium azide. An attractive model for studying stem cell differentiation within a live animal is the planarian flatworm. If it is a leg that is lost, a mechanism exists for. The merger strategy was based on a big bang approach in three steps. Stem cell systems and regeneration in planaria jochen c. These animals have evolved a remarkable stem cell system. During this investigation you will conduct an experiment to learn more about the. Planarians can regenerate an entire animal from almost any piece of their body in very few days. Jun 04, 2015 an artificial intelligence system has for the first time reverseengineered the regeneration mechanism of planariathe small worms whose extraordinary power to regrow body parts has made them a. Abstract the principles underlying regeneration in planarians have been explored for over 100 years through surgical manipulations and cellular observations.
On the date of this merger plan, the merging company holds 15,000 treasury shares. Concurrently, it engages all employees from the bottom up in the sharing of stories, developing common ground and commitment to organizational excellence. The purpose of this lab was to assess the regenerative abilities of planarians under differing environmental conditions. A planarian is one of many flatworms of the traditional class turbellaria. Planarian regeneration in volves the generation of ne w tissue at the wound site via cell proliferation blastema formation, and the remodeling of preexisting tissues to re store symmetry and.
The effect of temperature on the regeneration of planaria. Planarians are members of the platyhelminthes flatworms. Sunday, september th quest will host a town hall meeting at 12pm in the sanctuary. Planning for postmerger integrationeight lessons for. Pastor andy and the merger team will lead an open forum concerning the proposed merger to answer. Planarian worm regeneration and regrowing lost limbs human. Planarian regeneration involves the generation of new tissue at the wound site via cell proliferation blastema formation, and the remodeling of preexisting tissues to re. Regeneration definition and meaning collins english dictionary.
It must, therefore, be able to differentiate into any type of complex tissue the planaria requires for regeneration. Merger in the form attached as exhibit a hereto the certificate of merger with the secretary of the state of connecticut on or before march 15, 2017. Oct 25, 2012 school of molecular and cellular biology, university of illinois, urbana. An artificial intelligence system has for the first time reverseengineered the regeneration mechanism of planariathe small worms whose extraordinary power. Howard hughes medical institute 2006 holiday lectures on. Harbortown circle champaign, il 61821 at 7pm for a merger discussion. Regeneration in planaria phillip a newmark,carnegie institution of washington, baltimore, maryland, usa alejandro sa. Even though my experience was lacking, i still expected to obtain results that would answer the question. Merger implementation steps and issues a concept document 2. A single pluripotent adult stem cell type neoblast gives rise to the entire range of cell types and organs in the planarian body plan, including a brain, digestive, excretory, sensory and reproductive systems. The merger shall become effective as set forth in the certificate of merger the certificate of merger that shall be filed with the secretary of state of the state of delaware on the closing date. Acquirers should follow a proven post merger integration planning methodology playbook to define the integration steps and activities so that. The mouth is located in the center of the underside of the body. Therefore, currently there is no overarching regeneration plan for each neighbourhood that considers the key priorities and timescales for development.
The terms and conditions of the merger are as follows. Ttg today announced that with the proposed merger of the two comp. Migration of the customer database and contracts and management of intermediate period as the databases were migrated one month before the balance sheet 2. Identify and clearly communicate business objectives and expected synergies most senior executives spend considerable effort in developing the rationale and. Merger is a fusion between two or more enterprises, whereby the identity of one or more is lost and the result is a single enterprise whereas amalgamation signifies blending of two or more existing undertakings into one undertaking, the blended companies losing their identities and forming themselves into a separate legal identity. Regeneration is studied by simple amputation experiments that are easily performed in a basic laboratory and are amenable to pharmacological and genetic in vivo rnai manipulation as detailed by protocols in this article.
Regeneration capabilities are found in most or all animals. Pdf merger lite is a very easy to use application that enables you to quickly combine multiple pdfs in order to create a single document. Do the eyespots grow back more quickly or the photoreceptors. Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known. Planarians grow and degrow by changing overall cell numbers depending on food availability, leading to a 40fold variation in body size between 0.
This is a concepts document to assist in the planning and management of merger or acquisition implementation projects. In this type of amalgamation, not only is the pooling of assets and liabilities is done but also of the shareholders interests and the businesses of these companies. A recent example of how planarians can inform our understanding of regeneration and stem cell biology is provided by a study of the piwilike gene smedwi2 in s. Reactivating head regrowth in a regenerationdeficient. Regeneration technologies, tutogen medical announce new. The rnai screening approach, coupled with amputation and observation of regeneration steps, enables investigation of essentially any gene in regeneration. Subject to the provisions of this agreement, prior to the closing, the buyer shall prepare, and on the closing date the buyer shall cause to be filed with the secretary of state of the state of delaware, a certificate of merger the certificate of merger in such form as is required by, and. Planarian regeneration involves the generation of new tissue at the wound site via cell proliferation blastema formation, and the remodeling of preexisting tissues to restore symmetry and. The board of directors of east hill baptist church of pensacola, inc. Restoration of anterior regeneration in a planarian with. Planarian worm regeneration and regrowing lost limbs. Based on the situation on the date of this merger plan, the total number of shares in the recipient company to be issued as merger consideration would therefore be 83,876,431 shares. These remarkable plasticity depends upon the presence of a.